PRAXIS PRECISION MEDICINES INC.
TERMS OF USE

Last Updated: October 2026

READ THESE TERMS CAREFULLY. BY ACCESSING OR USING THE SERVICES, YOU AGREE TO BE BOUND BY THESE TERMS AND OUR PRIVACY POLICY, WHICH IS INCORPORATED HEREIN BY REFERENCE. IF YOU DO NOT AGREE, DO NOT USE THE SERVICES. IF YOU ARE ACTING ON BEHALF OF AN ENTITY, YOU REPRESENT THAT YOU HAVE AUTHORITY TO BIND THAT ENTITY TO THESE TERMS.

1. SCOPE AND ACCEPTANCE

These Terms of Use (“Terms”) are a binding agreement between you and Praxis Precision Medicines Inc. and its subsidiaries and affiliates (“Praxis,” “we,” or “us”). These Terms govern your access to and use of the Praxis website at https://praxismedicines.com, all related subdomains and redirects (the “Website”), any other website, mobile application, online portal, or social media page operated by or for Praxis that links to these Terms; any Text Program (as defined in Section 15); email and other electronic communications from Praxis; and any program, event, or other service offered by Praxis that references these Terms (collectively with the Website, the “Services”), and all content, data, text, graphics, images, software, and other materials available through the Services (“Materials”).

The Services are directed to users in the United States who are at least 18 years of age (or the age of majority in their jurisdiction) and capable of forming a binding contract. Access from jurisdictions where the Services are unavailable or contrary to local law is not authorized. Users outside the United States access the Services at their own risk and remain solely responsible for compliance with applicable local law.

Other Agreements; Products. If you have entered into a separate written agreement with Praxis, or a Service is subject to its own terms, consent form, or enrollment form (including any informed consent for a clinical study, patient support program enrollment form, or consulting or other services agreement), that agreement or document will control to the extent it conflicts with these Terms. These Terms do not govern any prescription products, which would be subject to their approved prescribing information, and do not apply to any claim relating to the use of a Praxis product.

2. CHANGES TO TERMS AND SERVICES

Praxis may modify these Terms or the Services at any time, without notice, by posting updated Terms on the Website. Your continued use of the Services after any modification constitutes your acceptance of the modified Terms. Praxis may suspend, restrict, or terminate your access to the Services at any time, for any reason, with or without notice.

3. NO MEDICAL OR PROFESSIONAL ADVICE

Nothing in the Services constitutes medical, clinical, scientific, legal, financial, or other professional advice, and nothing in the Services should be relied upon as such. Praxis is not a healthcare provider, and use of the Services do not create any physician-patient or other professional relationship. Always seek the guidance of a qualified healthcare professional for any medical questions or conditions. Never disregard or delay seeking professional medical advice because of something you read or receive through the Services.

4. FORWARD-LOOKING STATEMENTS

The Services may contain forward-looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995 regarding Praxis’s clinical programs, product candidates, regulatory strategy, and business plans. These statements involve known and unknown risks and uncertainties and are not guarantees of future performance. Forward-looking statements speak only as of the date made, and Praxis undertakes no obligation to update them. You should not place undue reliance on any forward-looking statements on the Services. For a description of applicable risks, refer to Praxis’s filings with the U.S. Securities and Exchange Commission.

5. INTELLECTUAL PROPERTY

The Services and all Materials are the proprietary property of Praxis or its licensors and are protected by US and international copyright, trademark, patent, and other intellectual property laws. All rights not expressly granted in these Terms are reserved.

Subject to your compliance with these Terms, Praxis grants you a limited, non-exclusive, non-transferable, revocable license to access and use the Services and Materials for personal, non-commercial, informational purposes only. You may not: (a) copy, reproduce, distribute, publicly display, or create derivative works of any Materials without Praxis’s prior written consent; (b) remove or alter any proprietary notices; (c) use any Praxis name, logo, or trademark without Praxis’s prior written consent; or (d) frame, mirror, scrape, or cache any part of the Services.

6. PROHIBITED CONDUCT

You agree not to use the Services to:

• Violate any applicable law, regulation, or third-party right;
• Transmit content that is unlawful, harmful, defamatory, obscene, fraudulent, or otherwise objectionable;
• Upload or transmit viruses, malware, or other harmful code;
• Use any automated means – including bots, scrapers, crawlers, or artificial intelligence tools – to access, collect, index, or extract any content from the Services without Praxis’s prior written consent;
• Attempt to gain unauthorized access to any part of the Services or their underlying systems;
• Interfere with or disrupt the Website or its servers;
• Impersonate any person or entity or misrepresent your affiliation with any person or entity;
• Transmit unsolicited commercial communications or harvest contact information;
• Commercially exploit, resell, or sublicense access to the Services or Materials; or
• Portray Praxis or its affiliates in a false, misleading, derogatory, or offensive manner.

Praxis reserves the right to investigate suspected violations and to terminate your access to the Services immediately and without notice.

7. USER SUBMISSIONS AND FEEDBACK

If you submit any communications, suggestions, ideas, or other materials to Praxis through the Services or otherwise (“Submissions”), you hereby assign to Praxis all right, title, and interest in and to such Submissions, including all intellectual property rights, without any obligation of confidentiality, attribution, or compensation. Where assignment is prohibited by law, you grant Praxis an irrevocable, perpetual, exclusive, worldwide, royalty-free, fully sublicensable license to use, reproduce, modify, publish, distribute, and exploit such Submissions for any purpose. Praxis is under no obligation to use, respond to, or acknowledge any Submission. Personal information included in a Submission is handled as described in the Privacy Policy.

You represent that any Submission you provide does not infringe any third-party rights and that you have full authority to grant the rights described above.

8. THIRD-PARTY LINKS AND CONTENT

The Services may contain links to third-party websites. These links are provided solely for convenience. Praxis does not control, endorse, or assume responsibility for any third-party websites, content, products, or services. Your use of third-party websites is at your own risk and subject to their respective terms and privacy policies.

9. DISCLAIMER OF WARRANTIES

THE SERVICES AND ALL MATERIALS ARE PROVIDED “AS IS” AND “AS AVAILABLE” WITHOUT WARRANTY OF ANY KIND. TO THE MAXIMUM EXTENT PERMITTED BY APPLICABLE LAW, PRAXIS EXPRESSLY DISCLAIMS ALL WARRANTIES, EXPRESS, IMPLIED, OR STATUTORY, INCLUDING ANY IMPLIED WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE, TITLE, ACCURACY, AND NON-INFRINGEMENT. PRAXIS MAKES NO WARRANTY THAT THE SERVICES WILL BE UNINTERRUPTED, SECURE, OR ERROR-FREE, OR THAT THE MATERIALS ARE ACCURATE, COMPLETE, CURRENT, OR RELIABLE. NO INFORMATION OBTAINED FROM PRAXIS OR THROUGH THE SERVICES CREATES ANY WARRANTY NOT EXPRESSLY STATED IN THESE TERMS.

10. LIMITATION OF LIABILITY

TO THE MAXIMUM EXTENT PERMITTED BY APPLICABLE LAW, IN NO EVENT SHALL PRAXIS, ITS AFFILIATES, OFFICERS, DIRECTORS, EMPLOYEES, AGENTS, OR LICENSORS BE LIABLE FOR ANY INDIRECT, INCIDENTAL, SPECIAL, CONSEQUENTIAL, PUNITIVE, OR EXEMPLARY DAMAGES – INCLUDING LOSS OF PROFITS, DATA, REVENUE, OR GOODWILL – ARISING OUT OF OR RELATED TO YOUR USE OF, OR INABILITY TO USE, THE WEBSITE OR MATERIALS, EVEN IF PRAXIS HAS BEEN SERVICES OF THE POSSIBILITY OF SUCH DAMAGES.

PRAXIS’S TOTAL CUMULATIVE LIABILITY TO YOU ARISING OUT OF OR RELATED TO THESE TERMS OR YOUR USE OF THE SERVICES, REGARDLESS OF THE FORM OF ACTION, SHALL NOT EXCEED ONE HUNDRED US DOLLARS ($100).

Some jurisdictions do not allow the exclusion or limitation of certain damages. To the extent such limitations are prohibited by applicable law, they shall apply to the fullest extent permitted.

11. INDEMNIFICATION

You agree to indemnify, defend, and hold harmless Praxis, its affiliates, and its and their respective officers, directors, employees, agents, successors, and assigns from and against any and all claims, liabilities, damages, losses, costs, and expenses (including reasonable attorneys’ fees) arising out of or related to: (a) your use of or access to the Services; (b) your violation of these Terms; (c) your violation of any applicable law or third-party right; or (d) any Submission you provide. Praxis may assume exclusive control of the defense of any matter subject to indemnification by you, at your expense. This indemnification obligation survives termination of these Terms.

12. DISPUTE RESOLUTION; GOVERNING LAW

These Terms and any dispute arising out of or related to the Services shall be governed by the laws of the Commonwealth of Massachusetts and applicable US federal law, without regard to conflict of law principles. You consent to the exclusive jurisdiction and venue of the state and federal courts located in the Commonwealth of Massachusetts.

CLASS ACTION WAIVER: TO THE MAXIMUM EXTENT PERMITTED BY APPLICABLE LAW, ALL DISPUTES MUST BE BROUGHT IN YOUR INDIVIDUAL CAPACITY AND NOT AS A PLAINTIFF OR CLASS MEMBER IN ANY CLASS, COLLECTIVE, OR REPRESENTATIVE ACTION. YOU WAIVE THE RIGHT TO PARTICIPATE IN ANY SUCH PROCEEDING.

JURY WAIVER: TO THE MAXIMUM EXTENT PERMITTED BY APPLICABLE LAW, EACH PARTY WAIVES ANY RIGHT TO A JURY TRIAL IN ANY ACTION ARISING OUT OF OR RELATED TO THESE TERMS OR THE SERVICES.

13. COPYRIGHT INFRINGEMENT (DMCA)

To submit a notice of claimed copyright infringement, please provide Praxis’s designated Copyright Agent at [email protected] with: (a) identification of the copyrighted work claimed to be infringed; (b) identification and location of the allegedly infringing material in the Services; (c) your contact information; (d) a statement of good-faith belief that the use is unauthorized; and (e) a statement under penalty of perjury that the information is accurate and you are authorized to act on behalf of the copyright owner. Counter-notices may be submitted to the same address. Praxis will process valid notices and counter-notices in accordance with 17 U.S.C. § 512.

14. PRIVACY

Your use of the Services are also governed by our Privacy Policy at https://praxismedicines.com/privacy-policy/, incorporated into these Terms by reference. Information collected through any Text Program (as defined in Section 15) is handled as described in the Privacy Policy.

15. TEXT MESSAGING PROGRAMS

Praxis may offer text messaging programs (each, a “Text Program”). This Section 15 applies to your participation in any Text Program, in addition to the rest of these Terms.

Consent. By opting in to a Text Program, you agree to receive recurring text messages (SMS/MMS) from Praxis Precision Medicines Inc. relating to that Text Program at the mobile number you provide, which may include reminders, alerts, and promotional messages, as described at the time you opt in. Messages may be sent using automated technology. Your consent is not a condition of any purchase. You represent that you are the subscriber or authorized user of the mobile number you provide.

Message Frequency and Charges. Message frequency varies. Message and data rates may apply to messages you receive from and send to Praxis. Please contact your wireless carrier with questions about your text messaging or data plan.

Opting Out. You may opt out of a Text Program at any time by texting STOP to the number from which you receive messages. You will receive one message confirming your opt-out, after which you will no longer receive messages from that Text Program unless you opt in again.

Help. For assistance, text HELP to the number from which you receive messages.

Change of Mobile Number. If you change your mobile number and wish to continue receiving messages, you must opt in again with your new number.

No Medical Questions or Side-Effect Reporting. Do not use a Text Program to ask medical questions, to seek emergency assistance, or to report side effects. See Section 3. If you are experiencing a medical emergency, call 911. To report a side effect, contact the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Delivery. Wireless carriers are not liable for delayed or undelivered messages. Message delivery is subject to effective transmission by your wireless carrier and is not guaranteed.

Changes and Termination. Praxis may modify, suspend, or discontinue any Text Program, or your participation in a Text Program, at any time, with or without notice.

16. GENERAL PROVISIONS

Entire Agreement. These Terms and the Privacy Policy constitute the entire agreement between you and Praxis regarding the Services and supersede all prior agreements regarding the Services, except as provided in Section 1 (Other Agreements; Products)..

Severability. If any provision of these Terms is unenforceable, it will be modified to the minimum extent necessary to make it enforceable; the remaining provisions remain in full force.

No Waiver. Praxis’s failure to enforce any provision does not waive its right to enforce that provision in the future.

Electronic Communications. By using the Services or contacting us electronically, you consent to receive electronic communications from Praxis, which satisfy any legal requirement that communications be in writing.

Assignment. Praxis may assign these Terms without restriction. You may not assign your rights or obligations under these Terms without Praxis’s prior written consent.

Survival. Sections 5, 7, 9, 10, 11, and 12 survive any termination of these Terms.

17. CONTACT

Questions about these Terms may be directed to:

Praxis Precision Medicines Inc.
99 High Street, 30th Floor
Boston, Massachusetts 02110
[email protected]